Associate Professor of Chemistry (573) 341-6950 Fax: (573) 341-6033 nercal@mst.edu

Education

Biography

Honors and Awards

Publications

In print and in press:

1. W. Wu, G. Goldstein, C. Adams, R. Matthews and N. Ercal, “Separation and Quantification of N-Acetylcysteine-amide (NACA) by HPLC with Fluorescence Detection,” Biomedical Chromatography, 20 (5): 415-422, 2006.

2. H. Gurer-Orhan, N. Ercal, S. Mare, S. Pennatur, H. Orhan, and Jay W. Heinecke," Misincorporation of Free meta-Tyrosine into Cellular Proteins: A Potential Cytotoxic Mechanism for Oxidized Amino Acids” Biochemical J, 395 (2): 277-284,2006.

3. N. Aykin-Burns and N. Ercal, “Effects of Selenocystine on Lead-exposed Chinese Hamster Ovary (CHO) and PC-12 Cells” Toxicol Appl Pharmacol, in press, 2006.

4. S. Penugonda, S. Mare, P. Lutz, WA Banks, and N. Ercal, “Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by acetylcysteine amide (NACA), a novel thiol antioxidant” Toxicol Appl Pharmacol, in press, 2006

5. T. Otamis-Price, F. Uras, W. A. Banks, and N. Ercal, “A novel Antioxidant, N-acetylcysteine amide prevents gp120 and tat-induced Oxidative Stress in Brain Endothelial Cells” Experimental Neurology, in press, 2006.

6. J. Ogony, S. Mare, W. Wu, and N. Ercal, “High Performance Liquid Chromatography Analysis of 2-Mercaptoethylamine (Cysteamine) in Biological Samples by Derivatization with N-(1-pyrenyl) maleimide (NPM) using Fluorescence Detection,” accepted for Biomedical Chromatography, 2006.

7. S. Mare, S. Penundago and N. Ercal, “HPLC Analysis of MESNA (2-mercaptoethane sulfonate) in Biological Samples Using Fluorescence Detection,” Biomedical Chromatography, 19(1): 80-86, 2005.

8. N. Aykin-Burns, E. A. Franklin, and N. Ercal, “Effects of N-Acetylcysteine on Lead-exposed PC-12 Cells”, Archives of Environmental Contamination and Toxicology, 49: 119-124, 2005.

9. R. Neal, N. Aykin-Burns, N. Ercal and J.S. Zigler, “Pb2+ Exposure Alters the Lens A-crystallin Profile In vivo and Induces Cataract Formation in Lens Organ Culture,” Toxicology, 212:1-9, 2005.

10. T. Otamis-Price, N. Ercal, R. Nakoke, W. A. Banks, “HIV-1 Proteins gp120 and Tat Induce Oxidative Stress in Brain Endothelial Cells” Brain Research, 1045(1-2):57-63, 2005.

11. Z. Qiang, O. Demirkol, N. Ercal, and C. Adams, “Impact of Food Disinfection on Beneficial Biothiol Contents in Vegetables” J. of Agriculture and Food Chemistry, 53:9830-9840, 2005.

12. S. Penugonda, S. Mare, G. Goldstein, WA Banks, and N. Ercal, “Effects of N-acetylcysteine amide (NACA), a Novel Thiol Antioxidant Against Glutamate-induced Cytotoxicity in Neuronal Cell Line PC-12,” Brain Research, 1056(2):132-138, 2005.

13. M. Du, W. Wu, N. Ercal and Y. Ma, “Simultaneous Determination of 3-nitro-Tyrosine, o-, m-, and p-Tyrosine in Urine samples by HPLC-UV with Precolumn Cloud Point Extraction,” J. of Chromatography B, 803: 321-329, 2004.

14. S. Penugonda, S. Mare and N. Ercal, “HPLC Analysis of N-(2-Mercaptopropionyl)-Glycine in Biological Samples by ThioGloTM3 derivatization,” Journal of Chromatography B, 807: 251-256, 2004.

15. W. Wu, and N. Ercal, “Determination of Thiocyl in Biological Samples by HPLC with ThioGloTM3 derivatization,” J. of Chromatography B, 809(2): 295-299, 2004.

16. O. Demirkol, C. Adams and N. Ercal, “Biologically Important Thiols in Various Vegetables and Fruits” J. of Agriculture and Food Chemistry, 52:8151-8154, 2004.

17. S. Penundago and N. Ercal, "Toxic Metals and Oxidative Stress Part II: Role of Antioxidants in Metal-induced Oxidative Damage," Current Topics in Toxicology, 1:53-71,2004.

In review:

18. S. Mare, G. Goldstein, and N. Ercal, "Protective effects of N-acetylcysteine amide against oxidative damage by H2O2-Cu (II) in vitro", submitted to Toxicology in Vitro, 2006.

Advising

Joshua Ogony (PhD)
Linu Abraham (PhD, Co-advised with Dr. Paula Lutz)

Teaching

Chem 361: Introduction to Biochemistry. Textbook: Biochemistry, Fifth Edition by Lubert Stryer.

Chem 362: Biochemistry laboratory course. Textbook: Biochemical Techniques Theory and Practice by John F. Robyt and Bernard J. White.

Chem 363: Metabolism. Textbook: Principles of Biochemistry by Lehninger, Nelson and Cox.

Biological Effects of Radiation: Guest lecturer.

Chem 464: Free Radicals in Biochemistry, a team-taught course (Dr. Lutz, Dr. Frank, and Dr. Leventis), based on recently published papers and relevant books. This course was adapted from that of Dr. Cadenas of University of Southern California, with his permission.